IIS: Lumevarin in chronic migraine with medication-overuse headache

EVP-0008Investigator-initiated studyLumevaFeasibility reviewRisk mediumSponsor: Investigator

NPDr. Nikolai PetrovHead of Evidence Generation & HEOR

Evidence gap: Outcomes in patients with medication-overuse headache
Objective: SO-LMV-02
Research question: Does lumevarin reduce monthly migraine days in chronic migraine with MOH?
Design: Open-label, single-centre, n=60
Investigator: Dr. Paola Castellano
Institution: Vall d'Hebron
Countries: Spain
Data source: Prospective
Submitted: 04 Aug 2026
Approved: —
Contract / ethics: Not startedEthics not required
Budget / spend: $0 of $220k
0%
Enrolment: 0 of 60
0%

Workflow

Evidence-generation workflow (PRD §17); Rejected is a terminal branch from any review stage.

Current stageFeasibility reviewDemo action — not persisted

Review stages passed, derived from workflow position

Study milestones from CTMS (INT-06)

Milestone	Due	Completed	Status	Evidence / note	Late days
Scientific review	05 Sept 2026	04 Sept 2026	Completed	Evidence missing	-1
Feasibility	31 Oct 2026	—	In progress	—	0

No linked publications

Insights citing the evidence gap "Outcomes in patients with medication-overuse headache"

Insight	Topic	Country	Priority	Status
INS-0039	Medication-overuse headache	ES	High	Action in progress

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